WEBVTT

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Yeah, I've

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been on high dose steroids
my whole life before I started CRENESSITY.

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It was really hard on me,
and um on my body.

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You're absolutely right.

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The steroids can have so many negative
effects on health.

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And the doses are, like, more
than you need to just replace cortisol.

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Risks of high dose
steroids can include weight gain,

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high blood pressure, high
cholesterol, and low bone density.

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It's tough because I know high androgen
levels can cause issues too, right?

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You're absolutely right.

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Excess androgens can cause infertility,

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Early puberty, excess hair
growth, and acne.

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So, you know, doctors
who are trying to treat CAH

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with just the steroids really
just struggle to balance the effects

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of the excess androgens
with the effects of the excess steroids.

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That makes sense to me.

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So with CRENESSITY,
I'm able to lower my androgen levels, right.

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So I'm able to take the lower steroid dose.
That's absolutely right.

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Possibly
just at the level needed to just replace

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the missing cortisol.
Nice. With CRENESSITY,

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we can directly manage androgens, lower
steroids, or do both.

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That's amazing. It gives me so much hope.

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I've been on CRENESSITY
for about two and a half years

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and, my androgens
have been lowered significantly.

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So that's been a really good thing for me.

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That's really wonderful to hear.
Thank you.

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Great. Congratulations. Thank you so much.

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Important safety information.

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Approved uses.

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CRENESSITY (crinecerfont) is a prescription
medicine used together

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with glucocorticoids

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(steroids) to control androgen (testosterone
-like hormone) levels in adults

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and children,

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4 years of age and older with classic
congenital adrenal hyperplasia (CAH).

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Important safety information.

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Do not take CRENESSITY

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if you are allergic to crinecerfont
or any of the ingredients in CRENESSITY.

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CRENESSITY may cause serious side effects,
including: Allergic reactions:

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Symptoms of an allergic reaction include
tightness of the throat, trouble breathing

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or swallowing, swelling of the lips,
tongue, or face, and rash.

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If you have an allergic reaction
to CRENESSITY, get emergency

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medical help right away
and stop taking CRENESSITY.

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Risk of sudden adrenal insufficiency
or adrenal crisis

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with two little glucocorticoid
(steroid) medicine.

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Sudden adrenal insufficiency
or adrenal crisis can happen in people

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with congenital adrenal hyperplasia

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who are not taking enough
glucocorticoid (steroid) medicine.

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You should continue taking

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your glucocorticoid (steroid) medicine
during treatment with CRENESSITY.

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Certain conditions
such as infection, severe injury, or shock

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may increase your risk for sudden adrenal
insufficiency or adrenal crisis.

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Tell your healthcare provider
if you get a severe injury,

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infection, illness,
or have planned surgery during treatment.

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Your healthcare

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provider may need to change your dose
of glucocorticoid (steroid) medicine.

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Before taking CRENESSITY,

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tell your healthcare provider
about all of your medical conditions,

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including if you are pregnant

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or plan to become pregnant,
or are breastfeeding or plan to breastfeed.

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Tell your healthcare provider
about all the medicines

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you take, including prescription
and over-the-counter medicines,

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vitamins and herbal supplements.

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The most

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common side effects
of CRENESSITY in adults include tiredness,

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headache, dizziness, joint pain, back
pain, decreased appetite, and muscle pain.

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The most common side
effects of CRENESSITY in children include

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headache, stomach pain, tiredness,
nasal congestion, and nosebleeds.

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These are not all the possible side
effects of CRENESSITY.

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Call your healthcare provider
for medical advice about side effects.

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You are encouraged to report negative side
effects of prescription

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drugs to the FDA.

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Visit MedWatch at

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www.fda.gov/medwatch
or call 1-800-FDA-1088.

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Dosage forms and strengths
CRENESSITY is available in 50 mg

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and 100 mg capsules
and as an oral solution of 50 mg/mL.

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Please see the accompanying full
Prescribing Information or find it at

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www.neurocrine.com/crenessityppi.