WEBVTT

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Ready?

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Let's do this.

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I'm really excited to talk to you.

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I've been on high dose steroids
my whole life before I started CRENESSITY.

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Being on a high dose,

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steroids have really,
it was really impacting my health.

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I got high blood pressure,

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type two diabetes.

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And all the weight gain,

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and the mood changes with the high dose steroids.

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For 70 years,

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you know, way
before I started medical school,

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all we had to treat CAH with was steroids.

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And as you know, the steroids
treat two things.

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First is to replace cortisol

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since your adrenal glands
can't make cortisol.

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And the second is to lower the excess
androgen levels.

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Oftentimes in CAH you need

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high doses to get the androgen levels
low enough. That makes sense.

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So, Dr. Lin, I know CRENESSITY
works differently from steroids.

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Can you explain to me a little bit more
how it works?

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So CRENESSITY is,

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you know, not
a steroid. CRENESSITY will be able

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to decrease the androgen levels separate
from the steroids.

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CRENESSITY binds
to CRF type one receptors.

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And then that interferes with the binding

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of CRF to the receptors,

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and, you know, consequently the decreasing
the signal to the adrenal glands.

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And that leads to a decrease in ACTH
and androgen levels.

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That's really helpful.

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I've been on CRENESSITY
for about two and a half years.

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Taking CRENESSITY has lowered my androgens
and decreased

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the amount of steroids I'm taking.

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CRENESSITY could potentially let doctors
treat patients like you

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with steroid levels
that are lower than the high levels

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that were needed to be used
for suppressing ACTH and androgens,

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possibly just at the level needed
to just replace the missing cortisol.

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It sounds like steroids help

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with my cortisol
and CRENESSITY helps with my androgens.

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That's absolutely right.

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After starting CRENESSITY
it's really important to,

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you know, be in close
contact with your doctor

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and talk to your doctor
about your symptoms and, about how to go

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about reducing the steroids
so that you can do it safely.

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Thank you so much, Dr. Lin.

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This conversation
has been really helpful for me.

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Important safety information.

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Approved uses.

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CRENESSITY (crinecerfont)

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is a prescription medicine used together
with glucocorticoids (steroids) to control

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androgen (testosterone-like hormone) levels
in adults and children, 4 years of age

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and older with classic congenital
adrenal hyperplasia (CAH).

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Important safety information.

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Do not take CRENESSITY

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if you are allergic to crinecerfont,
or any of the ingredients in CRENESSITY.

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CRENESSITY may cause serious side effects,
including: Allergic reactions:

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Symptoms of an allergic reaction
include tightness of the throat,

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trouble breathing or swallowing, swelling
of the lips, tongue, or face, and rash.

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If you have an allergic reaction
to CRENESSITY, get emergency

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medical help right away
and stop taking CRENESSITY.

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Risk of sudden adrenal insufficiency
or adrenal crisis

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with too little glucocorticoid
(steroid) medicine.

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Sudden adrenal insufficiency
or adrenal crisis can happen in people

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with congenital adrenal hyperplasia

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who are not taking enough
glucocorticoid (steroid) medicine.

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You should continue taking

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your glucocorticoid (steroid) medicine
during treatment with CRENESSITY.

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Certain conditions
such as infection, severe injury, or shock

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may increase your risk for sudden adrenal
insufficiency or adrenal crisis.

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Tell your healthcare provider
if you get a severe injury,

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infection, illness
or have planned surgery during treatment.

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Your healthcare provider may need

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to change your dose
of glucocorticoid (steroid) medicine.

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Before taking CRENESSITY,

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tell your healthcare provider
about all of your medical conditions

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including if you: are pregnant
or plan to become pregnant,

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or are breastfeeding or plan to breastfeed.

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Tell your healthcare provider
about all the medicines you take,

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including prescription

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and over-the-counter medicines, vitamins
and herbal supplements.

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The most common side effects
of CRENESSITY in adults include tiredness,

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headache, dizziness, joint pain, back
pain, decreased appetite, and muscle pain.

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The most common side effects of CRENESSITY
in children include headache, stomach

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pain, tiredness,
nasal congestion, and nosebleeds.

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These are not all the possible side
effects of CRENESSITY.

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Call your healthcare provider
for medical advice about side effects.

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You are encouraged to report negative side
effects of prescription

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drugs to the FDA.

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Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

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Dosage forms and strengths:

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CRENESSITY is available
in 50 mg and 100 mg capsules,

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and as an oral solution of 50 mg/mL.

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Please see the accompanying full
Prescribing Information or find it at

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www.neurocrine.com/crenessityppi.