WEBVTT

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We like to do a lot

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of hiking and so we're in the backcountry
and, we've done plenty of hikes

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that are long ones, seven, eight miles.

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So, with Grant having CAH,
that's absolutely

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something that's in the back of my mind
all the time.

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Now that we have CRENESSITY,
there are more options

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than just steroids for people with classic
CAH like Grant.

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The level of stress has gone down
significantly.

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My name is Grant,
and I love to play Fortnite.

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I love to do kinetic sand.

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I love climbing,
I love running and a bunch of other stuff.

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He always loves to paint.

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He loves to make slime.

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anything
that's messy, it's right up Grant's alley.

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So in the beginning, when we found out
Grant had CAH, our minds were just racing,

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wondering what our future was going
to bring, wondering if he was going to be

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just so sick, we'd have to keep him home
all the time. Every time we would take

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Grant to see his endocrinologist,
you know, we would have blood work done

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and we would always go over
all of his numbers with the doctor.

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Every single time we would go,
his numbers were always high.

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And his bone age
was significantly higher than his age

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and his numbers were showing
he was prepubescent at seven years old.

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Our doctor

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said it
was because his androgens were always high

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I just felt like we were always chasing
numbers. Just chasing the numbers

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rather than being proactive about it.

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I got a message one day

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and there was just this letter
inviting Grant to be a part of a study

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we had an appointment
with his endocrinologist.

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And she goes,
He is a prime candidate to try this.

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And it comes in a gel capsule.

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He had to learn how to swallow a pill.

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So we started with Tic Tacs

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and we slowly worked our way up
through M&Ms

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and eventually to Mike and Ikes,
of course, he's got brothers

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so all of his brothers were like,
I need to learn how to take pills

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and, you know,
so that they could get candy, too.

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He takes CRENESSITY in the morning
with breakfast

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and he takes it again
in the evenings with his dinner.

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Because CRENESSITY lowered Grant's
androgen levels.

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and 17-OHP

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his doctor was able to lower his steroid
dose.

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Before we started CRENESSITY
I had started noticing with him

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because we were getting into higher doses
of hydrocortisone and I was noticing

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he was really poofy, and that went away.

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Our doctor said it was because
of the decreased steroid dose.

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It's dropped by 40%

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and that's incredible.

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he really didn't look like that
little marshmallow anymore.

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Our doctor said the most common side effects

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in children were headache, stomach pain, tiredness,

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nasal congestion, and nosebleeds.

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If you have CAH

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and you're considering taking CRENESSITY,
It's done wonderful things for my son Grant.

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We/ve had a great experience
and it's been

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truly helpful. Hundred percent.

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Important safety information.

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Approved uses.

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CRENESSITY (crinecerfont)

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is a prescription medicine used together
with glucocorticoids (steroids) to control

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androgen (testosterone-like hormone) levels
in adults and children, 4 years of age

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and older with classic congenital
adrenal hyperplasia (CAH).

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Important safety information.

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Do not take CRENESSITY

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if you are allergic to crinecerfont,
or any of the ingredients in CRENESSITY.

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CRENESSITY may cause serious side effects,
including: Allergic reactions:

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Symptoms of an allergic reaction
include tightness of the throat,

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trouble breathing or swallowing, swelling
of the lips, tongue or face and rash.

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If you have an allergic reaction
to CRENESSITY, get emergency

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medical help right away
and stop taking CRENESSITY.

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Risk of sudden adrenal insufficiency
or adrenal crisis

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with too little glucocorticoid
(steroid) medicine.

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Sudden adrenal insufficiency
or adrenal crisis can happen in people

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with congenital adrenal hyperplasia

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who are not taking enough
glucocorticoid (steroid) medicine.

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You should continue taking

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your glucocorticoid (steroid) medicine
during treatment with CRENESSITY.

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Certain conditions
such as infection, severe injury, or shock

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may increase your risk for sudden adrenal
insufficiency or adrenal crisis.

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Tell your healthcare provider
if you get a severe injury,

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infection, illness
or have planned surgery during treatment.

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Your healthcare provider may need

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to change your dose
of glucocorticoid (steroid) medicine.

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Before taking CRENESSITY,

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tell your healthcare provider
about all of your medical conditions

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including if you: are pregnant
or plan to become pregnant,

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or are breastfeeding or plan to breastfeed.

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Tell your healthcare provider
about all the medicines you take,

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including prescription

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and over-the-counter medicines, vitamins
and herbal supplements.

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The most common side effects
of CRENESSITY in adults include tiredness,

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headache, dizziness, joint pain, back
pain, decreased appetite and muscle pain.

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The most common side effects of CRENESSITY
in children include headache, stomach

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pain, tiredness,
nasal congestion and nosebleeds.

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These are not all the possible side
effects of CRENESSITY.

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Call your healthcare provider
for medical advice about side effects.

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You are encouraged to report negative side
effects of prescription

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drugs to the FDA.

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Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088

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Dosage forms and strengths:

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CRENESSITY is available
in 50 mg and 100 mg capsules,

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and as an oral solution of 50 mg/mL.

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Please see the accompanying full
prescribing information or find it at

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www.neurocrine.com/crenessityppi.