WEBVTT

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So I started
playing tennis when I was four years old,

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I just played for 15 years and
I would play with like high level players

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like I would get sick

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sometimes. My coach knew I had something,
but he didn't necessarily know to CAH

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cause obviously he would want to push me
when I was playing and that makes sense.

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But then sometimes
I would have to tell him like, listen,

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It's not because I don't want to.

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I definitely consider myself
a driven person for sure.

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Again, I was the type of person
that never missed homework,

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like I never missed
a single assignment or deadline.

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And I think it was just like
my want to control my life

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I started taking control of my CAH,
like towards the end of high school.

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With CAH

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you might feel fine, but the blood results
don't show that necessarily.

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I kind of started to actually care about
like a lot of my results, a lot of my

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you know, blood work, etc.

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And I became more invested as well
in the trial or wanting to join a trial.

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I chose the CAHtalyst trial mainly
for the potential to lower my androgens

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and you know, lower my steroid usage.
I'm taking CRENESSITY twice a day,

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morning and night every day with a meal
My doctor told me

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some side effects of CRENESSITY are fatigue,
dizziness and joint pain.

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My personal experience, I didn't have
any side effects. After taking CRENESSITY

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my 17-OHP went down and my A4 went down.

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Because CRENESSITY lowered
my androgen levels,

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my doctor was able to lower
my steroid dose.

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It definitely went down from 25 milligrams,

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which was the baseline to about 17
and a half milligrams

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of hydrocortisone.

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Knowing that my lab results have gone down
because of CRENESSITY,

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I definitely feel better
about the long term like impact it

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did give me peace of mind that my levels
were on a more normal range.

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At the end of the day,

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I'm the one that's going
to be looking out for my future the most.

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I would tell people who are considering
CRENESSITY to talk with their doctor.

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I've had a good experience,
and you should talk to your doctor

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about what
your experience on CRENESSITY might be.

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Important safety information.

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Approved uses.

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CRENESSITY (crinecerfont)

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is a prescription medicine used together
with glucocorticoids (steroids) to control

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androgen (testosterone-like hormone) levels
in adults and children, 4 years of age

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and older with classic congenital
adrenal hyperplasia (CAH).

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Important safety information.

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Do not take CRENESSITY

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if you are allergic to crinecerfont,
or any of the ingredients in CRENESSITY.

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CRENESSITY may cause serious side effects,
including: Allergic reactions:

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Symptoms of an allergic reaction
include tightness of the throat,

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trouble breathing or swallowing, swelling
of the lips, tongue or face and rash.

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If you have an allergic reaction
to CRENESSITY, get emergency

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medical help right away
and stop taking CRENESSITY.

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Risk of sudden adrenal insufficiency
or adrenal crisis

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with too little glucocorticoid
(steroid) medicine.

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Sudden adrenal insufficiency
or adrenal crisis can happen in people

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with congenital adrenal hyperplasia

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who are not taking enough
glucocorticoid (steroid) medicine.

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You should continue taking

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your glucocorticoid (steroid) medicine
during treatment with CRENESSITY.

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Certain conditions
such as infection, severe injury, or shock

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may increase your risk for sudden adrenal
insufficiency or adrenal crisis.

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Tell your healthcare provider
if you get a severe injury,

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infection, illness
or have planned surgery during treatment.

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Your healthcare provider may need

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to change your dose
of glucocorticoid (steroid) medicine.

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Before taking CRENESSITY,

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tell your healthcare provider
about all of your medical conditions

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including if you: are pregnant
or plan to become pregnant,

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or are breastfeeding or plan to breastfeed.

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Tell your healthcare provider
about all the medicines you take,

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including prescription

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and over-the-counter medicines, vitamins
and herbal supplements.

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The most common side effects
of CRENESSITY in adults include tiredness,

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headache, dizziness, joint pain, back
pain, decreased appetite and muscle pain.

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The most common side effects of CRENESSITY
in children include headache, stomach

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pain, tiredness,
nasal congestion and nosebleeds.

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These are not all the possible side
effects of CRENESSITY.

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Call your healthcare provider
for medical advice about side effects.

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You are encouraged to report negative side
effects of prescription

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drugs to the FDA.

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Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088

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Dosage forms and strengths:

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CRENESSITY is available
in 50 mg and 100 mg capsules,

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and as an oral solution of 50 mg/mL.

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Please see the accompanying full
prescribing information or find it at

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www.neurocrine.com/crenessityppi.