WEBVTT

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I think the

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CAH community has been in a place
for a while where

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we're not seeing advances and to see that
there's actually something being done

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was exciting. It just didn't seem like
there were any breakthroughs.

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For me,

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I always wanted to find something better.

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I think that's kind of my personality is
I want to improve things, right?

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When CRENESSITY came out,
it gave me a new opportunity,

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like something
to look forward to like a big change.

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When I was born,
we didn't know I had CAH

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so I came home from the hospital
and after about a week and a half,

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they had to take me back.

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I was turning blue,

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I nearly died

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luckily one of the doctors was able
to figure it out.

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My younger brother also has CAH,
they knew that the risk was there.

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So they screened my brother
and were able to catch it early.

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Both having CAH, it really
it kind of gave you somebody to lean

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on a little bit, you know. As a kid
I did get kind of picked on.

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They called me like chipmunk
cheeks, right.

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I dealt with it,

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but it was just like one of those things,
right

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you know, you're a kid and like a high
schooler is making fun of you

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when you're getting on the bus
and you're like in third grade.[laughs]

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Some of the

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other challenges beyond that
I went through a few different doctors

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and I had, you know,
I was on high dosages of dexamethasone.

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One of the things I saw was,
you know, weight gain,

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especially in the face area.

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I received a kind of a cold call,

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and that is how I found out
about the CAHtalyst study.

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When I first received the call,

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I just really spent a few days
thinking about it

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and ultimately, you know,
I decided it was a good thing for me.

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It was going to be a good opportunity
to, you know, do something for the CAH

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community

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and then also at the same time,
you know, possibly help myself.

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You know, my mom always made the comment,
you know,

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there's a reason that you're here,
there's a special reason that you're here.

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Like there's a purpose
that I'm on this earth

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and it drives me. Incorporating
CRENESSITY was,

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it was pretty simple,
I take CRENESSITY twice a day with food.

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My doctor told me some of the common side
effects of CRENESSITY

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are fatigue, dizziness and joint pain.

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I didn't notice
any side effects from CRENESSITY.

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The doctor just really wanted
to make sure that I felt good

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and that my levels were in a good place.

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Since I began taking CRENESSITY,

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my steroid dose has dropped around 34%.

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You know, the
the moon face started to decrease.

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My doctor said it was because
of the decreased steroid dose.

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I just felt like a level of calm
that I had never felt in my life.

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I would highly encourage
my brother to look into CRENESSITY

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and I'm hopeful that it's something
that he'll start taking.

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Important safety information.

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Approved uses.

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CRENESSITY (crinecerfont)

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is a prescription medicine used together
with glucocorticoids (steroids) to control

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androgen (testosterone-like hormone) levels
in adults and children, 4 years of age

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and older with classic congenital
adrenal hyperplasia (CAH).

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Important safety information.

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Do not take CRENESSITY

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if you are allergic to crinecerfont,
or any of the ingredients in CRENESSITY.

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CRENESSITY may cause serious side effects,
including: Allergic reactions:

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Symptoms of an allergic reaction
include tightness of the throat,

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trouble breathing or swallowing, swelling
of the lips, tongue or face and rash.

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If you have an allergic reaction
to CRENESSITY, get emergency

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medical help right away
and stop taking CRENESSITY.

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Risk of sudden adrenal insufficiency
or adrenal crisis

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with too little glucocorticoid
(steroid) medicine.

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Sudden adrenal insufficiency
or adrenal crisis can happen in people

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with congenital adrenal hyperplasia

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who are not taking enough
glucocorticoid (steroid) medicine.

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You should continue taking

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your glucocorticoid (steroid) medicine
during treatment with CRENESSITY.

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Certain conditions
such as infection, severe injury, or shock

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may increase your risk for sudden adrenal
insufficiency or adrenal crisis.

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Tell your healthcare provider
if you get a severe injury,

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infection, illness
or have planned surgery during treatment.

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Your healthcare provider may need

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to change your dose
of glucocorticoid (steroid) medicine.

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Before taking CRENESSITY,

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tell your healthcare provider
about all of your medical conditions

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including if you: are pregnant
or plan to become pregnant,

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or are breastfeeding or plan to breastfeed.

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Tell your healthcare provider
about all the medicines you take,

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including prescription

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and over-the-counter medicines, vitamins
and herbal supplements.

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The most common side effects
of CRENESSITY in adults include tiredness,

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headache, dizziness, joint pain, back
pain, decreased appetite and muscle pain.

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The most common side effects of CRENESSITY
in children include headache, stomach

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pain, tiredness,
nasal congestion and nosebleeds.

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These are not all the possible side
effects of CRENESSITY.

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Call your healthcare provider
for medical advice about side effects.

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You are encouraged to report negative side
effects of prescription

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drugs to the FDA.

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Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088

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Dosage forms and strengths:

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CRENESSITY is available
in 50 mg and 100 mg capsules,

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and as an oral solution of 50 mg/mL.

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Please see the accompanying full
prescribing information or find it at

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www.neurocrine.com/crenessityppi.