WEBVTT

1
00:00:01.292 --> 00:00:03.169
I was transferred to

2
00:00:03.169 --> 00:00:06.881
Dallas where I ended up finding a doctor

3
00:00:06.965 --> 00:00:11.928 line:65%
and we sat and talked
and he wanted to be my doctor

4
00:00:12.012 --> 00:00:15.557
and he figured out I was overmedicated,

5
00:00:15.640 --> 00:00:19.144
both with the fludrocortisone and the steroids.

6
00:00:19.227 --> 00:00:23.857
So my blood pressure was extremely high
and weight gain.

7
00:00:23.940 --> 00:00:27.277
I learned about the CAHtalyst study
from my doctor.

8
00:00:27.360 --> 00:00:30.739
I decided to participate
because something had to change.

9
00:00:32.449 --> 00:00:34.743
I love the unknown

10
00:00:34.743 --> 00:00:38.788
and exploring new places,
meeting new people,

11
00:00:38.872 --> 00:00:41.416
trying new foods, seeing the world.

12
00:00:41.416 --> 00:00:46.004
I'm a compliance auditor for a major
airline in aircraft maintenance.

13
00:00:46.087 --> 00:00:50.467
So that allows me to travel the world
one airport at a time.

14
00:00:50.550 --> 00:00:53.261
I've been to about 35 countries.

15
00:00:53.261 --> 00:00:55.764
You know,
I talked to my mom quite a bit about this

16
00:00:55.764 --> 00:00:59.059
and she always said when someone says

17
00:00:59.142 --> 00:01:01.728
why, you would say, why not?

18
00:01:01.728 --> 00:01:03.897
Why can't I go do this?

19
00:01:03.897 --> 00:01:07.025
What's stopping me?

20
00:01:07.108 --> 00:01:07.567
I learned

21
00:01:07.567 --> 00:01:10.570
about the CAHtalyst study from my doctor,

22
00:01:10.612 --> 00:01:16.159
and I have been on other studies, and

23
00:01:16.242 --> 00:01:19.162
she recommended me for this one

24
00:01:19.162 --> 00:01:21.748
for the CAHtalyst study.

25
00:01:21.748 --> 00:01:26.211 line:65%
Incorporating CRENESSITY into my life
wasn't a very big change for me.

26
00:01:26.211 --> 00:01:26.836
It was,

27
00:01:26.836 --> 00:01:31.841
I took CRENESSITY twice a day with food
as directed.

28
00:01:31.925 --> 00:01:34.803
After taking CRENESSITY, my A4 levels

29
00:01:34.803 --> 00:01:38.306
did go down to a

30
00:01:38.389 --> 00:01:41.059
better range than what they were.

31
00:01:41.059 --> 00:01:45.063 line:65%
When I started taking CRENESSITY
I was on three different steroids.

32
00:01:45.146 --> 00:01:50.485 line:65%
Now I am only on the fludrocortisone, hydrocortisone.
My doctor told me

33
00:01:50.485 --> 00:01:55.615 line:65%
common side effects of CRENESSITY
are fatigue, dizziness and joint pain.

34
00:01:55.698 --> 00:01:57.909
I did not have any side effects

35
00:01:57.909 --> 00:02:03.039
when my steroid dose was lowered,
and I was put on to CRENESSITY.

36
00:02:03.123 --> 00:02:05.583
Yeah, the bar has changed absolutely.

37
00:02:05.583 --> 00:02:08.837
Now that CRENESSITY is out,
they were able to reduce

38
00:02:08.837 --> 00:02:13.299
the androgen levels
and A4 and reduce the steroids

39
00:02:16.177 --> 00:02:18.471
Important safety information.

40
00:02:18.471 --> 00:02:19.722
Approved uses.

41
00:02:19.722 --> 00:02:20.932
CRENESSITY (crinecerfont)

42
00:02:20.932 --> 00:02:24.894
is a prescription medicine used together
with glucocorticoids (steroids) to control

43
00:02:24.894 --> 00:02:28.857
androgen (testosterone-like hormone) levels
in adults and children, 4 years of age

44
00:02:28.857 --> 00:02:33.653
and older with classic congenital
adrenal hyperplasia (CAH).

45
00:02:33.736 --> 00:02:35.613
Important safety information.

46
00:02:35.613 --> 00:02:36.698
Do not take CRENESSITY

47
00:02:36.698 --> 00:02:40.535
if you are allergic to crinecerfont,
or any of the ingredients in CRENESSITY.

48
00:02:40.618 --> 00:02:44.080
CRENESSITY may cause serious side effects,
including: Allergic reactions:

49
00:02:44.122 --> 00:02:47.041
Symptoms of an allergic reaction
include tightness of the throat,

50
00:02:47.041 --> 00:02:51.379
trouble breathing or swallowing, swelling
of the lips, tongue or face and rash.

51
00:02:51.462 --> 00:02:54.007
If you have an allergic reaction
to CRENESSITY, get emergency

52
00:02:54.007 --> 00:02:57.218
medical help right away
and stop taking CRENESSITY.

53
00:02:57.302 --> 00:02:59.971
Risk of sudden adrenal insufficiency
or adrenal crisis

54
00:02:59.971 --> 00:03:02.974
with too little glucocorticoid
(steroid) medicine.

55
00:03:02.974 --> 00:03:06.686
Sudden adrenal insufficiency
or adrenal crisis can happen in people

56
00:03:06.686 --> 00:03:08.396
with congenital adrenal hyperplasia

57
00:03:08.396 --> 00:03:11.608
who are not taking enough
glucocorticoid (steroid) medicine.

58
00:03:11.691 --> 00:03:12.650
You should continue taking

59
00:03:12.650 --> 00:03:16.362
your glucocorticoid (steroid) medicine
during treatment with CRENESSITY.

60
00:03:16.446 --> 00:03:19.365
Certain conditions
such as infection, severe injury, or shock

61
00:03:19.365 --> 00:03:23.703
may increase your risk for sudden adrenal
insufficiency or adrenal crisis.

62
00:03:23.786 --> 00:03:26.122
Tell your healthcare provider
if you get a severe injury,

63
00:03:26.122 --> 00:03:29.709
infection, illness
or have planned surgery during treatment.

64
00:03:30.251 --> 00:03:31.544
Your healthcare provider may need

65
00:03:31.544 --> 00:03:34.255
to change your dose
of glucocorticoid (steroid) medicine.

66
00:03:34.255 --> 00:03:36.090
Before taking CRENESSITY,

67
00:03:36.090 --> 00:03:38.885
tell your healthcare provider
about all of your medical conditions

68
00:03:38.885 --> 00:03:41.679
including if you: are pregnant
or plan to become pregnant,

69
00:03:41.679 --> 00:03:43.890
or are breastfeeding or plan to breastfeed.

70
00:03:43.890 --> 00:03:46.601
Tell your healthcare provider
about all the medicines you take,

71
00:03:46.601 --> 00:03:47.560
including prescription

72
00:03:47.560 --> 00:03:51.814
and over-the-counter medicines, vitamins
and herbal supplements.

73
00:03:51.898 --> 00:03:55.193
The most common side effects
of CRENESSITY in adults include tiredness,

74
00:03:55.193 --> 00:03:59.989
headache, dizziness, joint pain, back
pain, decreased appetite and muscle pain.

75
00:04:00.073 --> 00:04:03.159
The most common side effects of CRENESSITY
in children include headache, stomach

76
00:04:03.159 --> 00:04:06.412
pain, tiredness,
nasal congestion and nosebleeds.

77
00:04:06.496 --> 00:04:09.457
These are not all the possible side
effects of CRENESSITY.

78
00:04:09.624 --> 00:04:13.002
Call your healthcare provider
for medical advice about side effects.

79
00:04:13.086 --> 00:04:15.588
You are encouraged to report negative side
effects of prescription

80
00:04:15.588 --> 00:04:17.131
drugs to the FDA.

81
00:04:17.131 --> 00:04:26.349
Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088

82
00:04:26.349 --> 00:04:28.935
Dosage forms and strengths:

83
00:04:28.935 --> 00:04:31.938
CRENESSITY is available
in 50 mg and 100 mg capsules,

84
00:04:31.938 --> 00:04:34.941
and as an oral solution of 50 mg/mL.

85
00:04:35.191 --> 00:04:39.195
Please see the accompanying full
prescribing information or find it at

86
00:04:39.195 --> 00:04:43.992
www.neurocrine.com/crenessityppi.