Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

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Susan, Paul, Liam, Allyson, Grant, & Kristy

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CRENESSITY StoriesHow CRENESSITY worksResources and Tools

CRENESSITY Stories

Explore real stories about CAH and CRENESSITY

Kristy and Grant’s story

Kristy talks about the impact of CRENESSITY on her 9-year-old son, Grant.

Paul’s story

Paul shares how CRENESSITY helped change the way he thought about his treatment goals for classic CAH.

Susan’s story

Susan discusses how she spent years dissatisfied with her treatment plan before starting CRENESSITY.

Liam’s story

Liam talks about how his search for a different way forward led to CRENESSITY.

CRENESSITY Conversations

Learn more as Lauren and Dr. Lin discuss CAH and how CRENESSITY works

What is CRENESSITY?

A brief intro to what CRENESSITY is and how it may help people with classic CAH.

How CAH affects the body

Dive into the science behind CAH.

How CRENESSITY works

Find out how CRENESSITY works—and how it’s different from any other treatment for classic CAH.

Impact of CRENESSITY

CRENESSITY changes what you can expect from classic CAH treatment.

Resources and Tools

Start the conversation about CRENESSITY.

Reach out to your doctor to find out if CRENESSITY might be right for you. Create a customized guide to help start the conversation—whether at an appointment or via phone, email, or patient portal.

Know Your Labs: Learn what they mean and how to talk to your doctor about them

Download Brochure

Download How to Take CRENESSITY guide

Download Brochure

Download Get to Know CRENESSITY, a comprehensive brochure for adults with classic CAH

Download Get to Know CRENESSITY, a comprehensive brochure for caregivers of children with classic CAH

Neurocrine Access Support

Learn about personalized, one-on-one support with CRENESSITY and about financial assistance options.

Next: Support

Please see full Important Safety Information

Approved Uses:
CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you:
Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:
Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.