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Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).
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Meet Grant

Shared by Grant’s mother, Kristy

Age 12

Grant is finishing up 5th grade and will be a middle schooler next year. He loves to hang out at home with his brothers and play video games with his friends.

Before CRENESSITY

Grant had early puberty and advanced bone age due to high androgen levels.

He was taking 22.5 mg of hydrocortisone daily, but those high steroid doses gave him “moon face” and overall puffiness.

Grant started CRENESSITY in May 2023

Grant participated in the clinical study for CRENESSITY in children.

Goals for starting CRENESSITY: It was frustrating to have no options other than steroids to manage his hormone levels. We hoped that with CRENESSITY we would see his androgen levels go down.

After starting CRENESSITY
  • His androgen levels are down by about 14% and continue to be well managed.
  • Since his androgen levels improved, we were able to lower his steroid dose from 22.5 mg daily to 12.5 mg daily.
  • Within a few months of decreasing his steroid dose, we noticed his “moon face” and puffiness went away.

We've had a great experience with Neurocrine Access Support. They've helped us navigate the process of accessing CRENESSITY.

Kristy and Grant are paid partners of Neurocrine. Grant has classic CAH and is taking CRENESSITY. Information here reflects Kristy and Grant’s personal experience with CRENESSITY.

Please read the Important Safety Information and reference the clinical trial information at CRENESSITY.com.
CAH=congenital adrenal hyperplasia.

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Please see full Important Safety Information

Approved Uses:

CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:

Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.

Please see full Important Safety Information

Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.