Questions about CRENESSITY?

You can start by sharing your treatment goals—like improving androgen control or reducing your steroid dose—and ask if CRENESSITY could help.

Your doctor can look at your lab results, symptoms, and current treatment to help decide if CRENESSITY is a good option for you.

Create a customized guide to help start the conversation

Headache, stomach pain, tiredness, nasal congestion, and nosebleeds were the most common side effects in children taking CRENESSITY.

Tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain were the most common side effects in adults taking CRENESSITY.

Your doctor can help you understand what to expect and how to manage any side effects.

These are not all the side effects of CRENESSITY. Please see full Important Safety Information and Patient Information

In clinical studies, the average time it took for headaches to subside was 5 days and about 18 days for tiredness, but some patients experienced these side effects for shorter or longer time frames.

3% of patients stopped taking CRENESSITY because of side effects.*

If you experience any side effects, call your doctor or pharmacist at PANTHERx. Do not stop taking CRENESSITY without talking to
your doctor first.

*_{A total of 3% of patients treated with CRENESSITY and no placebo-treated patients discontinued treatment because of adverse reactions of restlessness, apathy, dyspepsia, nausea, and vomiting.}

These are not all the side effects of CRENESSITY. Please see full Important Safety Information and Patient Information

Your coverage for CRENESSITY depends on your insurance plan, but with the help of Neurocrine Access Support, ~9 out of 10 people receive approval through their insurance.* If your insurance does not cover CRENESSITY, Neurocrine Access Support has financial support options^† that may be able to help get you access to your treatment.

*_{Data on file as of May 2026.}

^†_{Additional terms & conditions apply.}

Learn more about programs and resources available through Neurocrine Access Support

The Patient Assistance Program (PAP) may be an option; it may help you get access to CRENESSITY for free.* You may qualify if you don’t have insurance, your insurance doesn’t cover CRENESSITY, or you can’t afford your copay. Your doctor and your Care Coordinator with Neurocrine Access Support can check to see if you qualify and guide you through next steps.

*_{Additional terms & conditions may apply.}

Learn more about programs and resources available through Neurocrine Access Support

CRENESSITY targets the hormone imbalances that drive excess androgens in people with classic CAH.

In CAH, overproduction of the hormone ACTH leads directly to excess production of androgens. And before CRENESSITY, excess androgens were the reason many people with classic CAH needed high doses of steroids.

CRENESSITY is the only treatment that targets ACTH overproduction at its source so that lower levels are being made and less ACTH is present throughout the body. As a result of less ACTH being made, the body also produces fewer androgens—which means it’s possible to lower steroid doses, too.

Learn more about how CAH affects the body and how CRENESSITY works

About a month after starting CRENESSITY, your doctor can begin to work with you on a plan to reduce your steroid dose over time, guided by your lab results and symptoms.

As your dose is lowered, you may experience steroid withdrawal symptoms, such as fatigue, nausea, or mood changes. These symptoms are temporary and usually improve within a few weeks to months.

CRENESSITY does not treat adrenal insufficiency and adrenal crisis, which are 
risks of CAH if steroid doses are too low.

In the clinical trial of adults with classic CAH, adrenal crisis occurred in two 
patients taking CRENESSITY and in no patients taking placebo. However, one patient on placebo did experience adrenal insufficiency.

Talk to your doctor about managing your steroid dose while taking CRENESSITY.

Discover helpful videos and resources for managing classic CAH with CRENESSITY