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Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).
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Meet Olivia

Age 21

I’m a full-time student and am active in the campus community. I love playing games and going on adventures!

Before CRENESSITY

I dealt with irregular periods and acne growing up, which were tied to high androgen levels.

I was taking 6 mg of prednisone daily, and I experienced side effects related to high-dose steroids like weight gain and feeling puffy.

It was frustrating growing up trying to figure out if what I was experiencing was because of classic CAH. It was hard not to compare myself to my friends and not feel different.

I felt like I was in a rut. I just wasn't making progress managing my CAH and needed to see that there is hope for a change.

I started CRENESSITY in June 2025

Goals for starting CRENESSITY: I wanted my androgen levels to drop so that I wouldn’t have to take such high steroid doses.

After starting CRENESSITY
  • Within a few months, I started to notice changes. Over time, my androgen levels went down by about 50%.
  • Because of my improved androgen levels, my doctor was able to lower my steroid dose. I was even able to drop prednisone completely and switch to 22.5 mg/day of hydrocortisone, which is a milder steroid.
  • CRENESSITY helped to control my androgens. Because of the lower androgens, I saw improvements in my acne and my periods become more regular. And after my steroids were lowered, I also lost 20 pounds.

I’ve had nothing but amazing experiences communicating with the Care Coordinators and Neurocrine Access Support.

Olivia has classic CAH, is taking CRENESSITY, and was compensated by Neurocrine to share her story. Information here reflects Olivia’s personal experience with CRENESSITY.

Please read the Important Safety Information and reference the clinical trial information at CRENESSITY.com.

CAH=congenital adrenal hyperplasia.

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Their journey, in their own words

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Please see full Important Safety Information

Approved Uses:

CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:

Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.

Please see full Important Safety Information

Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.