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Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).
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Meet Paul

Age 45

I work for an electrical contractor and enjoy traveling with my wife and daughter, golfing, and attending sporting events.

Before CRENESSITY

The higher steroid doses I was taking to manage androgen levels led to weight gain and puffy cheeks—it made me lose hope that there would ever be a better way to treat classic CAH.

I struggled with androgen control—my A4 and
17-OHP numbers were consistently high.

I felt self-conscious about my appearance because of the consequences of high-dose steroids.

I started CRENESSITY in May 2021

Paul participated in the clinical study for CRENESSITY in adults.

Goals for starting CRENESSITY: I was hoping to be able to reduce my steroid dose with better androgen control.

After starting CRENESSITY
  • My labs 4 weeks after starting CRENESSITY showed that my androgen levels went down, and they continue to be well managed.
  • Before CRENESSITY, I struggled with having to increase steroid dosage and not always seeing great results. Now I’m able to take a lower dose of steroids since I’ve been maintaining better control of A4.
  • The reduced puffiness in my face is due to reducing my steroid dosage. This was something I had been teased about since I was a kid.

When CRENESSITY came out, it gave me a new opportunity, something to look forward to.

Paul has classic CAH, is taking CRENESSITY, and was compensated by Neurocrine to share his story. Information here reflects Paul’s personal experience with CRENESSITY.

Please read the Important Safety Information and reference the clinical trial information at CRENESSITY.com.​

17-OHP=17-hydroxyprogesterone; A4=androstenedione; CAH=congenital adrenal hyperplasia.

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Please see full Important Safety Information

Approved Uses:

CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:

Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.

Please see full Important Safety Information

Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.