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Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).
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Meet Wyatt

Age 20

I’m a full-time college student studying Fire Science in Colorado. Outside of school, I love exploring the outdoors and blacksmithing.

Before CRENESSITY

I experienced early puberty and advanced bone age, related to excess androgens.

I also struggled with weight gain and poor sleep, side effects related to the 30 mg of hydrocortisone and 2 mg of prednisone that I was taking daily.

I started CRENESSITY in June 2025

Goals for starting CRENESSITY: When I started CRENESSITY, my goals were to lower my androgen levels and reduce my high steroid doses.

After starting CRENESSITY
  • After starting CRENESSITY, my androgen levels came down and have stayed well managed.
  • With the improved androgen control, I was able to lower my hydrocortisone dose to 20 mg and drop prednisone entirely.
  • Since lowering my steroid doses, I have lost 35 pounds.

After I switched my health insurance, my Care Coordinator made it easy to continue CRENESSITY. They kept me well informed throughout every step, from prescription from my doctor to my shipments of CRENESSITY.

Wyatt has classic CAH, is taking CRENESSITY, and was compensated by Neurocrine to share his story. Information here reflects Wyatt’s personal experience with CRENESSITY.

Please read the Important Safety Information and reference the clinical trial information at CRENESSITY.com.

CAH=congenital adrenal hyperplasia.

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Their journey, in their own words

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Please see full Important Safety Information

Approved Uses:

CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:

Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.

Please see full Important Safety Information

Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.